Chemical Constituents from the Root Bark of Morus atropurpurea
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Abstract:
Mulberry root bark (Sang Bai Pi) was a kind of traditional Chinese medicine which showed hypotensive, antiviral bacteriostatic and anti-inflammatory activities. In order to explore the material basis of pharmacological activity of mulberry root bark, the chemical constituents of the root bark from Morus atropurpurea was studied in this paper. Fifteen compounds were isolated from the root bark by silica gel, Sephadex LH-20, ODS and PHPLC column chromatography. Their structures were identified by physicochemical properties and spectral analysis as kuwanon A (1), kuwanon B (2), kuwanon C (3), kuwanon T (4), cyclomorusin (5), moracin M (6), moracin O (7), moracin P (8), mulberrofuran L (9), albanin A (10) , australone A (11), 5'-(1',1'-dimethylallyl)-8-(3',3'-dimethylallyl)-2',4',5,7-tetrahydroxyfla-vone (12), 5,7-dihydroxycoumarin (13), oxyresceratrol (14) and β-daucosterol (15), respectively. Fifteen compounds contained eight prenylflavonoids, four 2-arylbenzofuran, one coumarin, one stilbene and one sterol. Moreover, compounds 1-4 and 7-13 were firstly found from Morus atropurpurea.
