Intervention Effect of Chimonanthus nitens Oliv. Leaf Extract on the Adipose Tissue of Mice
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Abstract:
The in vitro screening experiment found that Chimonanthus nitens Oliv. leaf alcohol extract and volatile oil significantly inhibited the activity of fatty acid synthase (FAS). During the in vivo experiments, mice were divided into normal group, intake-control group, high-dose of alcohol extract group, low-dose of alcohol extract group and volatile oil group whose weight and food intake were recorded every two days. The mice were killed after 30 days and a series of obesity indicators were measured to calculate Lee’s index, fat index and index of each viscera. The fat in mice was studied through hematoxylin-esoinstaining. Results indicated that Chimonanthus nitens Oliv. leaf extract affected the synthesis of body fat, which probably due to the inhibition of FAS and interference in the accumulation of fat. High-dose of alcohol extract group and volatile oil group greatly decreased by 7.19% and 6.96% respectively compared with normal group, fat index decreased by 42.04% and 36.73% respectively, TG decreased by 41.34% and 32.96% respectively, and TC decreased by 20.83% and 14.58% respectively. Moreover, the visceral index showed that the extracts had no significant toxic effects to the mice.
