Impact of Crude Polysaccharides from Abalone Viscera on the Physiological Function of Diabetic Mice
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Abstract:
In this study, effects of abalone viscera polysaccharide (AVP) on the glucose tolerance, serum glucose level, the antioxidant ability and organ protection of diabetic mice were investigated, in order to explore the AVP impact on the physiological function of diabetic rats induced by alloxan. Results showed that, the AVP model groups controlled the weight of mice significantlywhere. Especially for the high and middle dose groups (p<0.01), the weight of mice were 33.96 g and 32.95 g respectively after three weeks treatments. AVP lowered the blood glucose in diabetic mice and improved impaired glucose tolerance in a certain extent. The middle dose group (200 mg/kg) had the best effect, decreasing blood glucose to 15.45 mmol/L after three weeks. Meanwhile, the activity of SOD and GSH-Px promoted obviously, while the MDA content in blood serum reduced after three-week dosage. The activity of SOD, GSH-Px and MDA content of middle dose group were 155.25 U/mL, 529.63 μmol/L and 14.41 μmol/L, respectively, with significant difference compared to the control group (p<0.01). Moreover, AVP protected liver, kidney and spleen of sick mice, the viscera index of middle dose group were 5.23, 0.94 and 0.27, respectively, showing significant difference (p<0.05).
