Preventive Effect of Ilex kudingcha C.J. Tseng on Gastric Injury SD-rats
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Abstract:
Commercial Ilex kudingcha C.J. Tseng (KDC) was purchased from Chongqing market for the evaluation of gastric injury preventive effect in SD-rat. Two concentrations of KDC samples and omeprazole as pharmic control were tested. KDC and omeprazole reduced the levels of serum proinflammatory cytokines of IL-1β, IL-6, IL-8, and increased the IL-4 level as compared to the control in rats. SS and VIP serum levels of KDC and omeprazole groups were higher than those of the control group, while MOT and SP serum levels of KDC and omeprazole groups were lower than those of the control group. The gastric secretion volumes from high to low order were control rats, 500 mg/kg KDC-treated rats, 1000 mg/kg KDC-treated rats, omeprazole-treated rats, and normal rats, whereas pH levels of gastric juice showed the opposite trend. The gastric injury level was significantly decreased by KDC, demonstrating its anti-inflammatory properties. 1000 mg/kg of KDC showed the strongest anti-inflammatory effect that similar to the clinical drug omeprazole. For gastric tissues of KDC groups and omeprazole group rats, RT-PCR assay showed that the mRNA expression levels of inflammation-related genes of iNOS and COX-2 were significantly decreased, as compared with the control group. These results suggested that KDC had a gastric injury preventive effect as omeprazole.
