Polyketones from Aspergillus terreus Associated with Apostichopus japonicus
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Abstract:
Sea cucumber comprised of rich bioactive components is an important marine food and also used as a traditional medicine. There are various microbes associated with sea cucumber. In order to obtain effective bioactive compounds from Aspergillus terreus associated with Apostichopus japonicus from Zhifu Island, the fungus was cultivated on solid medium to investigate its secondary metabolites. Thin liquid chromatography (TLC), column chromatography and high performance liquid chromatography (HPLC) were used to separate secondary metabolites, and NMR, MS were used to identify their structures. As a result, dihydrogeodin (1), Territrems A (2), Territrems B (3), 1-(2, 4-dihydroxyphenyl)-ethanone (4), questin (5) and emodin (6) had been obtained and identified. KB and KBv200 were used to detect the cytotoxicity of 1, 5 and 6. It was the first time to determine intact Dihydrogeodin (1) by NMR and MS and it could be metabolized by marine fungus. In addition, it was firstly found that Territrem B (3) had the strongest inhibitory effects on acetylcholinesterase activities. Aspergillus terreus might be a new candidate for the development of functional food that can be used for preventing and treating Parkinson disease.
