Effect of Cyclocarya paliurus Polysaccharide on Hyperlipidemia and Anti-lipid Peroxidation in Hyperlipidemic Rats
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Abstract:
The hyperlipidemic rats were randomly divided into model control, simvastatin, Cyclocarya paliurus polysaccharides (CPP) low dose, middle dose, high dose groups (16 rats per group). After 8 weeks treatments, the levels of TC, TG, HDL-C, LDL-C, T-SOD, GSH-Px, CAT, T-AOC and MDA were measured. The results showed that CPP decreased serum TC, TG, LDL-C, MDA remarkably (P <0.01) with the decreasing rate of 29.17%, 50.00%, 57.25% and 25.72% respectively, while increased the levels of HDL, T-SOD , GSH-Px and T-AOC (P<0.01) with the highest growing rates of 72.22%, 16.27%, 16.38% and 59.43%. It was indicated that CPP could regulate lipid metabolism, enhance the anti-oxidation and reduce the lipid peroxidation in rats with hyperlipidemia.
