The Functions of Gut Clostridum spp. in Over-ingesting Energy of Body
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Abstract:
Obesity is colsely relative to the over-ingestion of gut microbiota on energy. It has been discovered that obesity is connected with bacteria of gut Firmicutes and Bacteroidetes recently. Reports present that Clostridum spp. is mainly responsible for the overenergy ingestion of body. Additionally, glycan-hydrolyzing enzymes from gut microbiota can break dietary fibres and produce short chain fatty acids that provide extra energy for body; more absorbance of bacterial lipopolysaccharide enhances the over-ingestion of energy; and energy can easily deposit as fat when the expression of fasting -induced adipose factor (FIAF) is inhibited. The above factors have all been reported to relate to obesity. But it remains unclear about what roles Clostridum spp. play during the process, including the main scource of the glycan-hydrolyzing enzymes, the contribution of short chain fatty acids (SCFA) during overenergy ingestion, the impact of Clostridum spp. on the production and absorption of bacterial lipopolysaccharide, and the factors influencing the expression of FIAF. This paper provided possible mechanism of Clostridum spp. involving in the process, which might be a reference for further study.
