Abstract:A new method was developed to determine three kinds of chloropropanols in chafing dish additives by gas chromatography with tandem mass spectrometry (GC-MS/MS) using isotope dilution technique. After spiked with isotope internal standards, the samples were eluted by chromatographic column, extracted with hexane and ether (1:1, V/V), and then purified by solid phase column (SPE). Trifluoroacetic anhydride (TFAA) was used as derivating agent. The targeted compounds were determined by GC-MS/MS and quantified by internal standard method. Under the optimized condition, the method could be accurately to simultaneously determine three kinds of chloropropanols in chafing dish additives products with two kinds of internal standards (1,3-dichloro-2-propanol-d5 and 3-chloropropane-1, 2-diol-d5) for calibration . Within the linear range of 50 to 1000 μg /L, the correlation coefficients were up to 0.999. The recoveries rates were between 82.5% and 104.0% with RSD less than 5% (n=6). This method is sensitive, accuracy, and the derivative agent is inexpensive, which is suitable for determining three kinds of chloropropanols in chafing dish additives.
