Antihypertensive Effects of Angiotensin-converting Enzyme (ACE) Inhibitory Peptides from Channel Catfish Skin Gelatin
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Abstract:
Fish skin is the main byproduct in channel catfish filet processing industrial. Preparation antihypertensive peptides using channel catfish skin gelatin can promote its utility value. Spontaneously hypertensive rats (SHR) and normal SD rats were used to assess the antihypertensive effects of the ACE inhibitory peptides under optimized condition in vivo. The ACE activity and Ang II contents in the serum and lung tissue of SHR were measured. The blood pressure of SHR was decreased significantly after one-time dosing experiment and long-term dosing study (28 days), and the antihypertensive effects were dose-dependent. The blood pressure of SHR in high dose group decreased from 206 mmHg to 159 mmHg after 2 h oral administration and remained around 155 mmHg after long-term oral administration for 10 days. Moreover, the ACE inhibitory peptides had no significant effect on normal SD rats. The ACE inhibitory peptide from channel catfish skin gelatin inhibited the ACE activity, and decreased the Ang II contents in serum and lung tissue of SHR. While there was no significant effect on ACE activity and Ang II content in serum and hung tissue for normal SD rats.
