Antioxidative Activity and Myocardial Protective Effect of Noni Extracts
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Abstract:
The protective effect of Noni extract on myocardial cell were investigated, and verified by the treatment of heart failure. The antioxidative activities of the noni extracts and two compounds separated from the extracts were studied and detected by five methods, namely elimination of ABTS, DPPH and hydroxyl free radical scavenging activities, cupric reducing power and total reducing power. The protective effect of myocardial cell was detected by flow cytometry and inverted fluorescence microscope, meanwhile ATP generaion from damaged myocardial cell was detected by HPLC. The order of the antioxidantive activities of the four compounds were shown as vitmin C >n-BuOH > rutin > flavonol glycoside. No difference of the myocardial apoptosis rate hwas found between the noni extracts(19.34%±2.24%) and vitamin C (21.51%±3.24%) at the final concentration of 100 mg/L (P>0.01). The noni extracts promoted the damaged myocardial cells. And myocardial ATP content 37.26±4.33 μg/g (24 h), 38.247±4.25 μg/g (48 h) was significantly higher than vitmin C 20.14±3.28 μg/g (24 h)，22.441±3.32 μg/g (48 h) (P<0.01). Thus noni extracts was a kind of safety antioxidant. The extracts could adjust the energy synthesis of the damaged myocardial cells and delay the process of heart failure.
