Extraction, Isolation and Antibacterial Mechanism of Antibacterial Peptides
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Abstract:
Long-term use of antiseptic and antibiotics has led to the development of resistance among pathogens and other pests as well as the increase of environmental and health risks. Thus, there is a significant and urgent need to find new antibiotics which hardly to induce resistance. Natural antimicrobial peptides, which are the critical component of the natural defense system, are kinds of small cationic peptides with broad antimicrobial activity, and possess a different mode of action compared to traditional antibiotics. Several antimicrobial peptides can inhibit and kill Gram-positive and Gram-negative bacteria, fungi, parasite, enveloped virus and cancer cells. Antimicrobial peptides are considered as new substitutes for conventional antimicrobials and antibiotics because of their efficiency in fighting against pathogens, and have a very good application prospect in pharmaceuticals and food additive industries. In this paper, we reviewed the research progress of antimicrobial peptides，and emphatically analyzed the extraction, isolation of the peptides and their antibacterial mechanism.
