Antioxidant and Antiproliferative Activities of Polyphenol Extract from 12 Tropical Fruits
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Abstract:
To evaluate the phenolic contents, antioxidant and antiproliferative activities of phenolic extracts from 12 tropical fruits, the total phenolic content was determined by Folin-Ciocalteu method and the antioxidant activity was measured with oxygen radical absorbance capacity activities (ORAC). The ferric reducing ability of plasma (FRAP), and the antiproliferative activity against human hepatoma cells (HepG2) were analyzed by MTT assay. It was founda that the total phenolic contents ranged from 26.17 to 229.67 mg gallic acid equivalents (GAE) per 100g fresh weight (FW). Averrhoa carambola had the highest phenolic content, being of 8.87-fold higher than Persea americana which had the lowest phenolic content. The ORAC and FRAP values were in the ranges of 607.05~2631.17 μmol TE/100g FW and 462.12~1067.92 μmol TE/100g FW, respectively. Averrhoa carambola showed the highest ORAC value which was 4.33 times higher than Carica papaya, and the higherst FRAP value which was 2.31 times higher than Persea Americana. The limits of IC50 values against HepG2 cells were from 31.79 to 66.93 mg/mL. Carica papaya had the lowest antiproliferative activity, with a 2.11-fold higher IC50 value compared to Averrhoa carambola with the highest antiproliferative activity. In addition, the total phenolic contents showed significant correlations with ORAC (R2＝0.7839), FRAP (R2＝0.7636) and IC50 values against HepG2 cells (R2＝0.8847).
