Antioxidant Effects of Fucoidan and Its Hydrolysates on Oxidative Damage Mice induced by D-galactose
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Abstract:
To investigate the antioxidant effects of fucoidan and its hydrolysates on D-galactose-induced senescent mice, hydrolysates of Fucoidan were prepared by EQFF degradation from high molecular weight Fucoidan. Kunming male mice were randomly divided into five groups: normal control group, oxidative injury model group, fucoidan group, hydrolysates of fucoidan group, and positive control group. Each group was injected with different drugs at the same dose for successive forty-two days. Then the indices of antioxidant effects both in serum and liver were determined. The results showed that both fucoidan and its hydrolysates had significant antioxidant effects compared with the model group. The inhibiting effects of fucoidan hydrolysates on hydroxyl radical of the mice feeding reached 500.67±35.67 U/mL (serum) and 1821.34±162.02 U/mgprot (liver), and the activity of T-SOD achieved were 101.82±3.98 U/mL (serum) and 3053.36±245.88 U/mgprot (liver). Meanwhile, the activity of CAT and GSH-Px in serum reached 4.05±0.56 U/mL and 348.88±29.22 U,respectively. It was indicated that the low-molecular- weight fucoidan hydrolysates had higher antioxidant influence on D-galactose-induced senescent mice than high- molecular- weight fucoidan.
