Physicochemical Properties of the Complex of Hesperidin and Hydroxypropyl-β-cyclodextrin
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Abstract:
Hesperidin possesses many bioactivities, such as antioxidant, antibacterial, lowering blood pressure, antiviral, antitumor and improving immunity, which can be used in functional food, medicine and cosmetics. But its poor solubility in water limited its wide applications. In this study, the complex of hesperidin and hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared to improve the water solubility of hesperidin by solvent method. Meanwhile, the physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). The results showed that the physical phase of hesperidin was significantly changed . It was completely dispersed in HP-β-CD matrix after inclusion. Hesperidin and HP-β-CD were combined with non-covalent bonds such as hydrogen bond and Van der Waals' force. HPLC analysis showed that the solubility of hesperidin in water at 30 ℃ was increased from 34.68 μg/mL to 2049.50 μg/mL
