Antihypertensive Effect of Bioactive Extracts from Morchella conica
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The antihypertensive effect of bioactive extracts from Morchella conica (BEMC) was studied in order to provide a theoretical basis for further exploitation of M. conica. The rats were intraperitoneally injected with L-NNA to settle the hypertensive model, and were orally administrated with different doses of the BEMC (50 mg/kg, 100 mg/kg and 200 mg/kg per day) for 28 d. Systolic blood pressure, heart rate, weight, heart index, liver index, brain index, kidney index and the contents of serum angiotensin II (AngⅡ), nitro oxide (NO) and blood urea nitrogen (BUN) were examined to evaluate antihypertensive effect of BEMC. Compared with the model group, the systolic blood pressures of the rats with the above-mentioned doses of BEMC were decreased by 17.79%, 6.99% and 17.24%, respectively. For the rat at 100 mg/kg dose of BEMC The level of serum NO of the rats at 50 mg/kg dose of BEMC was increased by 6.79%. The levels of kidney index, liver index and serum BUN of the rats were severally decreased by 5.16%, 4.89%, and 10.06%, respectively. And for that with low and middle dosages of BEMC (50 mg/kg and 100 mg/kg), the levels of serum AngⅡof the rats were severally decreased by 10.98% and 27.29%, respectively. And the levels of heart rate of the rats were severally decreased by 7.51% and 5.26%, respectively. In addition, the levels of heart index of the rats were severally decreased by 7.66% and 9.75% , respectively.
