Bioinformatic Analysis of Genes Relative to the Carcinogenic Toxicity of Aflatoxin B1
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Abstract:
Aflatoxin is one of the most harmful mycotoxins existing extensively in daily food, among which carcinogenic toxicity of aflatoxin B1(AFB1) showed the highest carcinogenic toxicity. To screen genes strongly associated with the carcinogenic effects of AFB1, three AFB1-related human genome microarray datasets were downloaded from GEO database and analyzed by clustering and bioinformatic retrieving in this study.A set of genes were selected for clustering, which expression differences were greater than 2 fold in three microarray datasets. Then the genes expressed in accordant trend in the cluster analysis were screened and the genomic information about those genes and the association with AFB1 were determinated. Several genes such as KRT15, PCNA and MMP1 were identified as key AFB1-related genes through bioinformatics analysis on three relative microarray datasets,. These data may be benefit for further investigations of the genesis and progression of the AFB1-induced cancer．
