mmunological and Antitumor Activities of the Polysaccharides from Pholiota nameko
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Abstract:
Guinea pig blood serum was chosen as the complement to study anticomplement research and mouse peritoneal macrophages RAW264.7 was used for toxicity test. The capabilities of macrophage englobing neutral red and secreting NO and H2O2 were investigated to study Pholiota nameko polysaccharides (PNP) immunocompetence. The antitumor activities of the PNP were studied through prostatic cancer 22Rv.1 cells and human hepatoma Hep 2B cells inhibition. The results showed that the PNP owned good anticomplement activity and activity of PNP was strengthened with its concentration increased.when increasing the polysaccharides to 12.5 mg/mL above. In concentration of 0.005~0.5 mg/mL, PNP could promote the proliferation of macrophages and peritoneal macrophage phagocytic ability, and increased NO and H2O2 secreting, indicating that PNP had good immunological activity. PNP had strong inhibition to the prostate cancer cells and liver cancer cells, with a concentration-response relationship.
