Dephlogisticate, Antitussive and Expectorant Effects of Polysaccharides from Exocarpium citri grandis on Mice
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Abstract:
The dephlogisticate ,antitussive and expectorant effects of the polysaccharides from Exocarpium citri grandis (ECP) were studied. The models of edema induced by xylene, cough induced by concentrated ammonia water and phenel red execretion in mice were used to observe the dephlogisticate effect, the antitussive effect and the expectorant effect, respectively. Result showed that ECP could inhibit the edema induced by xylene in mice. The swelling inhibition rates in low, middle and high dose group were 24.93%, 34.84% and 48.72%, respectively. The swelling inhibition rate in the positive control group was 52.83%. It was also found that ECP could prolong cough incubation period and reduce the cough times in 2 minutes induced by concentrated ammonia water. There was a significant difference (P < 0.01) between the control group and the middle/high dose groups, which meant that the ECP could increase phenel red execretion in mice. ECP showed a significant dephlogisticate, antitussive and expectorant effects.
