Optimization of Extraction Process of Ginsenoside from Panax quinquefolius L. Collected from Canada by Response Surface Methodology
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Abstract:
The Response Surface Methodology (RSM) was used to optimize the extraction process of ginsenoside from P. quinquefolius L. collected from Canada. Based on one-factor-at-a-time experiments, extract yield of the ginsenoside-Rb1 was used as response for establishing a quadratic regression model. Temperature and time of extraction, ethanol concentration and liquid-to-solid ratio were selected as the factors for RSM design. The results showed that the best extraction conditions were as follows: extraction temperature 90 ℃, extraction time 1.88 h, ethanol concentration 77.4%, solid-liquid ratio 1:25, and extracted times twice, under which the predicted yield of ginsenoside-Rb1 with the optimized procedure was up to 1.40%and practical yield was 1.41%.
