Immunomodulating Activity of Exopolysaccharides from Lactobacillus casei LC2W
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Abstract:
EPS synthesized by L.casei LC2W from different carbon sources (glucose or lactose) were fractionated. The neutral polysaccharides G1 and G2 were two kinds neutral polysaccharides synthesized by L.casei LC2W using glucose as carbon source. Another two kinds of neutral polysaccharides synthesized by L.casei LC2W using lactose as carbon sources were named as L1 and L2. All the two kinds of polysachharides showed little cytotoxicity to lymphocytes cultured in vitro. On the contrary, all of the 4 EPS fractions demonstrated strong inhibitory activity for the proliferation of B-lymphocytes stimulated by bacterial liposaccharides in vitro. In the range of 5~80 μg/mL, the inhibitory activities of G1 and L1 to the proliferation of B-lymphocytes were negatively correlated to the concentration of EPS. And the inhibitory activities of G2 and L2 were positively correlated to the concentration of EPS. The carbon sources in the growth medium might be a decisive factor for the composition and even the bioactivity of the EPS synthesized by L. casei LC2W.
