Antioxidant Activity and Antiproliferation Effect on Tumor Cells of Phlorotannins from Sargassum integerrimum
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Abstract:
To investigate antioxidant activity and antiproliferation effect of phlorotannins extraction from Sargassum integerrimum (IPTs) IPTs was prepared by solvent extraction and ultrafiltration. Four extracts named IPTa1, IPTa2, IPTe1 and IPTe2 were attained. Total phenolic contents of the four IPTs were 1.16, 0.6, 0.25 and 0.34 mg GA/g algae dry base. Total antioxidant capacities of the four extracts at 1.5 mg/L were equal to reduction capacities of Fe2+at 1.724, 1.379, 1.833 and 0.695 mg/L, respectively. MTT results showed that the four extracts except IPTa2 inhibited significantly proliferation of thyroid squamous cell carcinoma cells (sw579) at the concentration of 4.4 μg/mL and their inhibition rates increased in a time-dependant manner within 72 hours. Inhibition rates of IPTa1 and IPTe1 had a positive correlation with time and concentration at range of 0.3125~5 μg/mL and the highest inhibition rate was up to 90%.
