Abstract:According to procedures for toxicological assessment of supplement food, acute toxicity test, genetic toxicity test (Ames test，micronucleus test of born marrow in mice，sperm shape abnormality test in mice) and thirty-day feeding test in rats were conducted to assess toxicological safety of mice and rats fed with Kduzu-glucosamine formula. The results showed that mouse oral LD50 was above 20.0 g/(kg?bw). Ames test and micronucleus test of bone marrow cells and sperm shape abnormality test in mice were all negative. Rats after being fed Kduzu -glucosamine Formula for 30 d with three different doses groups grew well. Hematology and hematology biochemistry index were all normal. No abnormal symptoms were observed after gross anatomy. Kduzu-glucosamine formula belongs to the actual innocuous level and no-genetic toxicity, being used according to recommending amounts is safe.
