The Toxicological Assessment on Safety of Compound Capsule of Soy Isoflavone
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Abstract:
30 days feeding test was used in this study to assessment the safety of compound capsule of soy isoflavone according to the procedures for toxico logical assessment of food. the physical signs, behavior,stooll and fur of the rat in each dose (166.7, 333.3, 666.7 mg/kg?bw) No abnormal phenomen was found in the samples. Compared with control group, the weight, food utilization rate, blood routine, organ coefficients and biochemical indexes of the rat in each dose were no significant differences (P>0.05)..Blood biochemical indicators (ALT, AST, BUN, Crea, TP, ALB, GLU, T-cho and TG) were not significant (P>0.05). The pathologic examination of main organs was the same, and no special pathological changes were found. As compared with the model aging control group (7.13±1.16 nmol/mL), all dose groups (67.0,133.0 and 200.0 mg/kg?bw) was significantly lower in the levels of serum MDA content for the experiment of antioxidation effects in mice, Erythrocyte SOD activity (6.49±0.41, 6.74±0.50, 7.22±0.34, ×103Nu/mL) were significantly higher than the control group (6.29±0.88 ×103Nu/mL).Therefore, the soybean isoflavone compound capsule was safe and had a significant antioxidant in this study.
