Effects of Peptide from Rape Pollen Glutelin on Hemopoietic Function Promotion of Mice Irradiated by 60Coγ
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Abstract:
To evaluate the protective effects of peptide from rape pollen glutelin on hemopoietic function promotion of irradiated mice in 60Coγ, and to provide theoretical evidence for developing the safe and harmless antiradiation medicine and improving added value of pollen. The mices were divid The protective effects of peptide from rape pollen glutelin (PRPG ) on hemopoietic function promotion of irradiated mice in 60Coγ were evaluated in this research to provide theoretical evidence for developing the safe and harmless antiradiation medicine and improving added value of pollen. The mice were divided into normal control group, irradiating control group, low, medium, and high dose group. For 30 days of being intragastricaly administrated, all mice were irradiated by 8 Gy 60Co-γ-ray except normal control group. Then the peripheral blood WBC, RBC, PLT and HGB of mices were analysis on fixed days. 20 days of radiation later，the activity of SOD in hepatic tissue and MDA content in serum were studied, and the DNA content of bone narrow , the rate of nucleated bone narrow cell were detected. Comparing with the model group, the mice of PRPG peripheral blood WBC, RBC, PLT and HGB were higher. The rate of nucleated bone narrow cell was decreased,. The DNA content of bone narrow and the activities of SOD in liver were increased, and MDA in serum were decreased. And the 100 mg / kg.bw dose group was found to be the best. PRPG had protective effects on hemopoietic function promotion of irradiated mice in 60Coγ.
