Synthesis and Sensory Evaluation of New Cooling Agent Menthyl Formylamines Compounds
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Abstract:
Menthyl chlorine was synthesized by chlorinated reaction of L-menthol and Lucas reagent, then reacted with magnesium. Menthane-3-carboxylic acid was synthesized by the Grignard reagent of Menthyl Chlorinum and CO2. And then menthyl carboxyly chloride was obtained by thionyl chloride. Finally, N-ethyl-menthyl-3- carboxamide(a), acetic acid(N-ethyl- menthyl -3-carboxamide) ethyl(b), N-tert- butyl-menthyl-3-carboxamide(c) and N-(4–methoxy-phenyl)-menthyl-3-carboxamide(d)were synthesized by ethylamine, glycine ethyl ester hydrochloride, tert-butyl amine and anisidine with menthyl carboxyly chloride respectively. All structure of target compounds was characterized by IR,1HNMR and MS. The corresponding threshold of 5a, 5b, 5c and 5d was 0.3 μg/mL, 0.2 μg/mL, 0.1 μg/mL and 0.4 μg/mL by sensory evaluation.
