Influence of Fed-batch Fermentation on Gentamicin Production of Micromonospora
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Abstract:
In order to enhance gentamicin production and build up the foundation for comprehensive experiment in Bio-pharmaceutical Technology, the influence of fed-batch fermentation on the gentamicin production of Micromonospora in a 10 L fermentor was studied.The result showed that fermentation production under frequent small amounts feeding pattern was better than that under the feeding pattern with large amounts at once. Increasing the amount of dissolved oxygen under the frequent small amounts feeding pattern not only extended production phase, but also increased fermentation productivity to 87.3%. It was concluded that the optimized fed-batch pattern can not only extend fermentation period, but also improve the yield of gentamicin.
