Abstract:To study the effects of ethanol extracts from Rubus corchorifolius L.f leaves (RE) on four different models of mice diarrhea， different models of mice diarrhea were induced by senna, castor oil, magnesium sulfate and Escherichia coli, and six groups were set up, including blank control group (BC), model control group (MC), positive drug control group, high/middle/low dosage of RE(RH, RM, RL). The indexes of amounts of loose stools and the level of loose stools were observed and the diarrhea index was calculated. Compared with MC group, the diarrhea index of RE groups induced by senna was reduced significantly during 0~3 h (P<0.01); the diarrhea index of RH and RM groups induced by castor oil was reduced significantly during 0~5 h (P<0.05). The diarrhea index of RM group induced by Escherichia coli was reduced significantly during 0~2 h (P<0.01). The diarrhea index of RH and RM groups induced by magnesium sulfate was reduced significantly just during 0~1 h (P<0.01). There were significantly induction of RE on the diarrheal models induced by senna, castor oil, and Escherichia coli, while weak effect on the magnesium sulfate one.
