Toxicological Evaluation of Enzymatically-Hydrolyzed Borojoa Concentrated Powder
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Abstract:
The safety of enzymatically treated Borojo concentrated powder was evaluated through animal experiments, including acute toxicity test, mouse bone marrow micronucleus test, sperm shape abnormality test in mice and 30-day feeding study. Results showed that the oral acute toxicity LD50 of male and female mice was above 21.5g/kg?bw. Enzymatically treated Borojo concentrated powder was nontoxic substances based on the acute toxicity grading. The mouse bone marrow micronucleus test and mouse sperm abnormality test results showed no significant differences with the control group. The 30-day feeding study in rats showed that the weight gain, food utilization, the ratio of dirty and body, hematologic and blood biochemical index of the animals in each dose group had no significant differences with the control group. The pathological examination showed little obvious toxic pathological changes in major organs. The enzyamtically treated Borojo concentrated powder was considered as a safe food.
