Oxidation Degradation of Chitosan for Preparation of Oligochitosan
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Abstract:
Chitosan (COS) with 96.7% deacelation degree was degraded oxidatively by hydrogen peroxide in order to prepare oligochitosan with polymerization. The optimal reaction conditions were discussed by means of some single factor experiments and orthogonal experiments. COS was dissolved in 4.0% acetic acid with 4.0% hydrogen peroxide at 60 ℃ shaking for 6 hour. The distribution of COS and the degraded COS under optimal conditions were analyzed by gel permeation chromatography (GPC). The results showed COS had been completely degraded with the molecular weight being below 2000. The polymerization degree of degraded COS was below 10 after been detected and analysed by electro-spray ionization mass spectrometry (ESI-MS), which was in the control range of degradation.
