Aessessment of the Probiotc Properties of Lactobacillus Strains
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Abstract:
The four L. paracasei supsp. paracasei stains were examined in vitro in a two-stage model system comprising simulated gastric and intestinal juices., adhesion capability to HT-29 cells, antagonistic activity against enteric pathogens and immunomodulating activity. The strains L. paracasei supsp. paracasei M5AL and J23ANL were able to survive in simulated gastro juice while the strains L. paracasei supsp. paracasei G15AL and T3AL lost viability exposed to simulated gastro juice for 3 h. The four strains had high viability in simulated small intestinal juice with little loss (<1.0 cycle reduction). The strain L. paracasei supsp. paracasei M5AL and G15AL had adhesive capability to HT-29 cells in vitro (>40 bacteria cells per 100 HT-29 cells). The strains L. paracasei supsp. paracasei M5AL and G15AL could inhibit the growth of the E. coli ATCC25922, S. typhimurium ATCC 14028, S. sonnei ATCC 25931. The live bacteria of the four strains could exert proliferative effect on PBMCs.
