Effect of Yunnan wild Elsholtzia Oil on Learning and Memory in Offspring Mice
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Abstract:
This study aimed to investigate the effect of Yunnan wild elsholtzia oil on learning and memory function of mouse offspring . From the first day of pregnancy, Kunming mice were divided into five groups: blank control group, positive control group, low-dose, medium-dose and high-dose groups and were intragastrically administrated with the elsholtzia oil gavage till being weaned. According to intragastic administration dose for the pregnant rats, the weanedmale mouse was intragastically administrated till 49 days after birth and then tested for the Morris water maze test. The fatty acid contents of the liver and brain organization were detected. Compared to the blank control group, navigation test showed that each group were statistically significant (p<0.01) in the 5 th day. Space exploration experiment showed that only the positive control group was statistically significant (p<0.05). By analysis of TPro, NO, AchE , it was found that he positive control group, medium-dose and high-dose groups were statistically significant (P<0.05). The contents of the fatty acids in liver of the positive control group and the high-dose group were statistically significant (p<0.05). Contents of oleic acid and ALA in high-dose group were statistically significant (p<0.05) in brain tissue. ALA-riched eElsholtzia oil can partly enhance the learning and memory in mouse offspring mouse., due to the hihger TPro and ALA contents but lower NO and AchE contents by feeding ALA-riched elsholtzia oil.
