Rregulation Effect of Fresh Mangosteen Saponins on Blood Sugar
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Abstract:
To study blood sugar regulation effect of Fresh Mangosteen Saponins (FMS), normal mice were orally administrated with FMS for one day or seven days. At 30 min after, intragastric administration with starch, sucrose or glucose respectively, Glycemic index (GI), insulin concentration and inhibition rate of α-glucosidase were determined. Result showed that single dosage of FMS inhibited GI of tarch and sucrose significantly, but had no effect on GI of glucose. After 7 days administration of FMS, GI of both tarch and glucose were inhibited, GI and the peak value of blood glucose are reduced. FMS administration increased postprandial insulin concentration significantly, and FMS dose-dependently inhibited α-glucosidase activity. It was concluded that FMS produced significant inhibition of postprandial blood glucose in normal mice, this effect is mediated primarily by inhibition of food glucose transformation and insulin increasing. When compared with the dry mangosteen saponin, FMS demonstrated higher insulin-increasing effect than dry mangosteen saponin, while the α-glucosidase inhibitory activity was weaker.
