Chromatography Technology for Monitoring the Synthesis of β-D-Glucopyranosides
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Abstract:
Two glycosidically bond flavor precursors 2,3,4,6-tetraacetyl-geranyl-1-O-β-D-glucopyranoside (GLY-A) and geranyl-β-D-glucopyranoside (GLY-B) were stereo-synthesized by the modified Koenigs-Knorr reaction. Thin layer chromatography (TLC) was used to monitor the reaction. Silica gel column chromatography was used for separating and purifying the samples.By reverse phase HPLC (RP-HPLC), the purity of GLY-A and GLY-B were analyzed as 98.2% and 96.0%, respectively. The chromatography technology was suitable for the monitoring of the stereo-synthesis of glycosides in monitoring, separation and analysis, obtained an ideal experimental results.
