Preparation of Sulfured Polysaccharides from Cordyceps gunnii and its Anti-oxidation Activity
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Abstract:
In this study, 70% polysaccharides from Cordyceps gunnii (Berk.) Berk. were chemically modified via sulfation and was renamed as SPS70 (Cordyceps gunnii 70% sulfated polysaccharides). The structure, property and bioactivity of SPS70 were subsequently investigated. Infrared spectroscopy analysis demonstrated that SPS70 possessed sulfate groups. After modification, the neutral polysaccharides were turn into acidic polysaccharides. After purification by DEAE-sephadex A-25, the purity of SPS70 reached 92.72% and GPC anlysis showed that its molecular weight was of approximately 8490 Da. Anti-oxidation analysis revealed that the radical scavenging ability of SPS70 towards superoxide anion increased when increasing the final concentration of the polysaccharide. And the maximum hydroxyl and DPPH scavenging properties were abstained when SPS70 concentration was of 2.5 mg/mL, being of 71.23% and 64.12%, respectively.
