Protective Effects of Tea-Orange Tablets on Alcoholic Hepatic Injury
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Abstract:
Tea-Orange Tablets were made from extracts of Satian pomelo and tea. Acute and chronic alcoholic hepatic injury animal models were setup to test the protective effects of tea-orange tablets from pomelo peel and tea extract. Acute alcoholic hepatic injury mice models were setup by oral administration of 50% alcohol twice a day for 10 days. Compared to control group, tea-orange tablets (100 mg/kg, 300 mg/kg and 900 mg/kg) could reduce serum TG and MDA contents, and improve activity of GSH-Px, showing dose dependence (p<0.001). Chronic alcoholic hepatic injury rat models was setup by oral administration of 50% alcohol (4 g/kg, p.o.) and 25% CCl4 (0.1 mL/kg, i.p.) for 8 weeks. Oral administration of tea-orange tablets (70, 210 and 630mg/kg) could significantly reduce contents of ALT, MDA and CHO, and improve contentsof ALB and activity of SOD (p<0.001). Tea-orange tablets were in rich of flavones material and had protective effects to acute and chronic alcoholic hepatic injury.
