Optimization of Fermentation Medium for γ-Aminobutyric Acid Production by Lactobacillus brevis
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Abstract:
Gamma-aminobutyric acid (GABA) has many physiological functions and is a major inhibitory neurotransmitter in mammalian nervous systems. Fermentation medium for GABA production, based on MRS medium, was optimized using single factor test, orthogonal design and Response Surface analysis method. The best carbon source and nitrogen source were determined as glucose and the mixture of soybean and corn steep liquor, respectively. Under the optimum conditions, the content of GABA in optimum fermentation medium reached 27.12 g/L, which was 93.30% higher than that of original fermentation medium (14.03 g/L).
