Abstract:Bagasse cellulose sulfate (BCS) was achieved via homogeneous sulfation of Bagasse Cellulose (BC) in ionic liquid [BMIM]Cl and structurally elucidated by 13C NMR. It was found that the substituent distributions of sulfate differed with the reaction time, firstly occurring in C6 place, and then in C2 and C3 places. In vitro investigation of the antibacterial activities of BCS showed that BCS could inhibit Escherichia coli and Staphylococcus aurous. Its antibacterial activity would be improved by increasing the BC concentration.