Synthesis of Methamphetamine-Bovine Serum Albumin Conjugates
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Abstract:
To synthesize the methamphetamine antigen for immunoassay. Functional group was introduced into methamphetamine and then methamphetamine antigen was synthesized by anhydride method using BSA as carrier protein. The reaction was monitored by FTIR, UV scanning, protein electrophoresis and GICA methods. Results: 25 molecules of methamphetamine were conjugated to one molecule of BSA. And the formed conjugate showed confirmed antigenic Activity. Methamphetamine antigen was successfully synthesized and could be used in immunoassay.
