Abstract:The anti-aging effect of Cordyceps gunnii (Berk.) Berk. Polysaccharide (G-50) on the senescent mice was studied. D-galactose-induced senescent mice were divided into model, low-dose, middle-dose and high-dose groups. 11 Days later, the mice of the low-dose, middle-dose and high-dose groups were gastricly lavaged with 50% polysaccharide with its dose being of 100, 200 and 400 mg/kg, respectively. After 45 days, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the MDA contents in serum and brains were observed. Results showed that Cordyceps gunnii (Berk.) Berk. polysaccharide improved SOD and GSH－Px activities and obviously inhibited the formation of MDA in serum and brains, indicating that the Cordyceps gunnii (Berk.) Berk. polysaccharide had good anti-aging effect.
