The effects of several influential factors on the water extraction of baicalin were investigated by single factor experiment using UV-spectrometry for the determination of baicalin content. The extraction conditions were further optimized by orthogonal design. Results showed that, when the materials were crushed into pieces, the best water-solid ratio, reflux extraction times and the extraction time per times were 8, 3, and 1.5 h, respectively, under which the extraction yield reached 23.0491%.
