Preliminary Investigation of the Effect of Low-Sodium Intake on Hypertention-related Gene Network
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Abstract:
Objective: to investigate the effect of low-sodium intake on the expression of hypertention related genes. Method: Six people were apportioned into a control and a patient group (n=3 each) to take the low-sodium intake for two months. Their total RNA samples were extracted, purified and treated by reverse-transcription. Then the gene expression profiles were analyzed by 22 K Human Genome Array experiments. Result: Among the 150 hypertension candidate genes, differences in some gene expression were found in both of the examined groups (the ratio of >2 and<0.5 were regarded as up-regulated and down-regulated expression, respectively). The expression levels of ADA and NPRB genes were decreased in the patient group, while that of the SLC8A1 gene increased in both the groups. Conclusion: Our preliminary investigations provided evidence that consumption of low-sodium salt could adjust local network status of some hypertension candidate genes functionally linked with iron channels/transporters.
