Study on Immune Function of the S180 Tumor-bearing Mice Cured by Cartilage Polysaccharide
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Abstract:
Objective: To study the immune function of the S180 tumor-bearing mice cured by cartilage polysaccharide, the effects of virucidal S180 tumor on immune function of the mice and the mechanisms. Methods: The influences of the blood serum, spleen cells and thymucytes of the S180 ascites tumor-bearing mice cured by cartilage polysaccharide on the S180 tumor and MCF-7 breast carcinoma cells were measured using the MTT method. Virucidal S180 tumor cells were injected into healthy mice and their effect on immune functions of the mice were investigated. Results: The blood serum, spleen cells and thymucytes of the S180 tumor-bearing mice cured by cartilage polysaccharide had definite inhibitory effects on tumor growth. When cultured in the RPMI 1640 culture-medium, the inhibition rates of 10% blood serum of the S180 tumor-bearing mice cured by cartilage polysaccharide reached 64.09 %, 73.48 %, respectively, while those of 20% blood serum of the mice were 88.70 % and 96.80 %, respectively. Conclusion: The S180 tumor-bearing mice cured by cartilage polysaccharide had definite immune functions on tumors.
