Marine sponge is a kind of symbionts with many species. It grows in a very complicated environment with a very special route of metabolism so there are abundant metabolites. The study on bioactive peptides from marine sponge is up and doing now. The analysis of the structure of bioactive peptide from marine sponge, the bioactivities of marine sponge, such as anti-tumour, anti-virus, anti-bacteria and so on, were reviewed. It was pointed out that marine sponge is an infinite storeroom of medicine. And the prospect of the application of bioactive peptides form marine sponge was viewed.
