Abstract:The synthesis of N-succinyl-chitosan and properties were studied. Results showed that the concentration of methanol and acetic acid and the molar ratio of anhydride to amino group affected the degree of N-succinylation. To prepare N- succinyl-chitosan, the optimal MeOH concentration, AcOH concentration and the range of mole ratio of anhydride to amino group were 80 %, 5 % and 4, respectively. It was also found that the degree of N-succinylation had effect on both the solubility and gelation of N-succinyl-chitosan.