Influence of Addition of Tween-80, Toluene and Aether on the Liquid Fermentation of Monascus GM011
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Abstract:
The influence of toluene, aether and tween-80 on the liquid fermentation of Monascus GM011 was studied due to their capability of changing the cell membrane permeability. Results showed that toluene not only inhibited the growth of GM011 and the production of Monacolin K and red pigment, but also greatly influenced the morphology of GM011, while tween-80 could promote the growth of the fungus, favor the production of red pigment and inhibit the production of Monacolin K. When aether was added to the fermentation liquid, little effect was found on the growth of GM011, the production of red pigment and the morphology of GM011, while it greatly improved the production of Monacolin K. By adding 1 mL aether into 100 mL broth per 24 h, the concentration of Monacolin K was up to 425 mg/L, which is 2.53 times higher than that of the control.
