鞣花多酚是一类天然酚类化合物,广泛存在于覆盆子、草莓和石榴等多种食物中,表现出多种生物活性,如抗肿瘤和抗炎等作用。然而,研究表明鞣花多酚在体内的生物吸收率较低,这可能与其结构复杂性和较大的分子量密切相关。目前国内尚未见鞣花多酚生物吸收和代谢的系统综述,其生理活性受生物吸收与代谢影响的机制仍然不清楚。基于鞣花多酚葡萄糖核上的不同基团连接类型,本文提出了一种新的分类方法,以利于理解鞣花多酚的生物吸收与其特征基团的关系。在此基础上,本文系统回顾了鞣花多酚的代谢途径及其影响因素,重点讨论了生理条件、化学结构和摄入剂量等因素对鞣花多酚及其代谢产物在体内吸收与代谢的影响,并从代谢机制角度分析了鞣花多酚的结构特征如何影响其生理活性。本综述为鞣花多酚的代谢及功能活性研究提供了新的视角和新思路。

Ellagitannin polyphenols are a class of natural phenolic compounds widely found in a variety of foods such as raspberries, strawberries and pomegranates, and exhibit a variety of biological activities such as anti-tumor and anti-inflammatory effects. However, studies have shown that ellagic polyphenols have low bioabsorption in vivo, which may be closely related to their structural complexity and large molecular weight. A systematic review of the bioabsorption and metabolism of ellagic polyphenols has not yet been conducted in China, and the mechanism by which their physiological activities are affected by bioabsorption and metabolism remains unclear. Based on the different types of motif linkages on the glucose nucleus of ellagic polyphenols, a new classification method is proposed in this paper to facilitate the understanding of the relationship between the bioabsorption of ellagic polyphenols and their characteristic motifs. On this basis, this paper systematically reviews the metabolic pathways of ellagitannin polyphenols and their influencing factors, focusing on the effects of physiological conditions and factors such as chemical structure and intake dose on the absorption and metabolism of ellagitannin polyphenols and their metabolites in vivo, and analyzes how the structural features of ellagitannin polyphenols affect their physiological activities from the perspective of metabolic mechanisms. This review provides new perspectives and new ideas for the study of the metabolism and functional activities of ellagic polyphenols..