纳豆水解酪蛋白肽片（简称蛋白肽片），主要以水解酪蛋白肽、纳豆粉、弹性蛋白肽等为原料制备而成。该研究旨在探究蛋白肽片对自发性高血压大鼠的降压作用及机制。以自发性高血压大鼠为模型，每天灌胃口服给药4周后，检测大鼠的体质量、血压、血清及血管。蛋白肽片可以改善自发性高血压大鼠的体质量下降。结果在结束灌胃的第10周时，与模型组相比，蛋白肽片可降低血清中的血管紧张素Ⅱ（Angiotensin Ⅱ，Ang Ⅱ），醛固酮（Aldosterone，ALD）和增加降钙素基因相关肽（Calcitonin Gene Related Peptide，CGRP）的含量。与模型组相比，蛋白肽片可降低总胆固醇（Total Cholesterol，TC）含量，甘油三酯（Triglyceride，TG）和低密度脂蛋白胆固醇（Low Density Lipoprotein，LDL-C）的含量，增加CGRP的含量，差异具有统计学意义。蛋白肽片还改善高血压大鼠血管壁增厚现象，改善血管弹性，减少血管内皮免疫细胞的聚集。在该实验条件下，蛋白肽片不仅对自发性高血压大鼠有明显的降血压作用，同时有利于改善高血压大鼠的血清生化指标和血管功能。

Protein peptide tablets consisting of hydrolyzed casein peptides, natto powder, and elastin peptides were used in spontaneously hypertensive rats to investigate antihypertensive effects. The tablets were administered by oral gavage for 4 weeks and the responses in body weight, blood pressure, serum, and vascular tissue of the rats were examined. The protein peptide tablets improved body weight reduction in spontaneously hypertensive rats. Comparison with the control group indicated that protein peptide tablets lowered the content of angiotensin Ⅱ (Ang Ⅱ) and aldosterone (ALD) and increased the content of calcitonin gene-related peptides (CGRP) in the serum by the 10th week of administration. Protein peptide tablets substantially lowered total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) content. The protein peptide tablets improved vascular wall thickening and elasticity in hypertensive rats while reducing the accumulation of immune cells in the vascular endothelium. Under the experimental conditions of this study, the protein peptide tablets had a marked antihypertensive effect but also improved the serum biochemical indicators and vascular function of spontaneously hypertensive rats.

国家自然科学基金项目（22178070）；广东省重点领域研发计划项目（2022B1111080003）