L-抗坏血酸（L-ascorbic Acid, ASC）具有良好的抗氧化性，除了在维持人类健康和预防坏血病方面的作用外，ASC还可作为食品工业中的有效抗氧化剂。ASC在液体食品中应用广泛，但其在水溶液中的稳定性较差，易在光、热等条件下降解。为了改善ASC在水溶液中的稳定性，该研究使用共结晶技术将ASC与小分子糖形成低共熔物，通过液体辅助球磨法，制备了ASC和蔗糖（Sucrose, SUC）、葡萄糖（D-Glucose, GLU）、海藻糖（Trehalose, TRE）的低共熔物。结果表明，所有低共熔物均表现出显著降低的熔点，微观结构从不规则大块状转变为更均匀的小颗粒状。在pH值为3.50、4.50、7.00的条件下，低共熔物对ASC的保护效果分别为纯ASC的1.05、1.17、1.78倍，证明低共熔物可以提高ASC在水溶液中的稳定性，在中性环境下的保护效果最优。选取pH稳定性中保护效果最好的SUC-ASC-1.5 H低共熔物，经高温和紫外照射处理后，在酸性环境中的保护效果最优，约为纯ASC的1.09~1.33倍。该研究成功制备了三种糖与ASC的低共熔物，证明了低共熔物在加工不利条件下能够抑制ASC在水溶液中的氧化降解，为增强ASC的水相稳定性提供了新的方法，也为开发更稳定的ASC功能性食品和保健品提供新的研究方向。

L-ascorbic acid (ASC) is well-known for its excellent antioxidant properties. In addition to its significant role in maintaining human health and preventing scurvy, ASC is widely used as an effective antioxidant in the food industry. Despite its widespread application in liquid foods, ASC is poorly stable in aqueous solutions, where it readily degrades under light and heat. To improve the stability of ASC in aqueous solutions, this study employed co-crystallization technology, using liquid-assisted ball milling to prepare eutectic mixtures of ASC with sucrose (SUC), D-glucose (GLU), and trehalose (TRE). The results demonstrated that all eutectic mixtures exhibited significantly reduced melting points. The microstructure of the eutectic mixtures was transformed from irregular large blocks to more uniform small particles. Under pH conditions of 3.50, 4.50, and 7.00, the protective effect of eutectic mixtures on ASC was 1.05, 1.17, and 1.78 times greater, respectively, compared to pure ASC, confirming that eutectic mixtures can enhance ASC stability in aqueous solutions, with the most effective protection observed under neutral condition. The SUC-ASC-1.5 H eutectic mixture, which exhibited the best pH stability, was selected for further study. It was shown to provide optimal protection in acidic environments, with its protective effect ranging from 1.09 to 1.33 times greater than pure ASC after exposure to high temperatures and UV light. In this study, three types of sugar-ASC eutectic mixtures were successfully prepared, and their ability to inhibit the oxidative degradation of ASC in aqueous solutions under unfavorable processing conditions was demonstrated. The findings offer a new method for enhancing ASC's stability in aqueous environments and provide new research directions for developing more stable ASC-based functional foods and health products.

2022年汕头市精细化工企业引进科技领军人才团队及进口替代技术攻关项目（STKJ202211008）；国家重点研发计划项目（2022YFD2101302）