该文研究了富含玉米黄质色素橄榄油（Olive Oil Rich Zeaxanthin，OZT）对衰老小鼠的影响。将亚急性衰老模型造模成功的小鼠分为模型组、OZT高中低处理组、橄榄油组（Olive Oil，OL）、维生素E阳性（Vitamin E，VE）对照组，以生理盐水为CK（0）组。连续灌胃28 d后，分析不同剂量OZT对衰老小鼠的体重、脾脏和胸腺指数、耐缺氧和抗疲劳作用、血清中SOD（Superoxide Dismutase）、CAT（Catalase）、GSH-Px（Glutathione Peroxidase）、ALT（Alanine Aminotransferase）、AST（Aspartate Aminotransferase）活性和MDA（Malondialdehyde）、IL-2（Interleukin-2）、IL-4、IL-10、IFN-γ（Interferon-γ）生成水平等指标的影响。结果显示，建模灌喂给药28 d后，Model组体质量与CK组小鼠相比存在极显著差异（P<0.01），而灌胃OZT的高中低剂量小鼠的体质量之间均存在显著差异（P<0.05）；灌胃后OL组小鼠的耐缺氧时间和游泳时间最短，而OZT的高剂量组的小鼠时间最长，与VE组相比无显著差异（P>0.05）；OZT还能降低衰老小鼠血清中的ALT、AST、SOD、CAT和GSH-Px的活性，提高IL-2、IL-4、IL-10和IFN-γ生成，降低MDA含量，且OZT高剂量组效果显著优于OL组，与VE接近。综上，OZT对D-半乳糖致亚急性衰老动物模型有很好的干预效果，能有效提高小鼠机体抗氧化能力，延长耐缺氧时间和提高抗疲劳作用，延缓衰老的作用。

The effects of olive oil rich zeaxanthin (OZT) on aging mice were investigated. Divide mice successfully modeled in subacute aging into model groups, OZT High, middle and low treatment group, olive oil group (OL) , vitamin E positive (VE) control group. After continuous gavage for 28 days, to analysis the effects of different doses of OZT on body weight, major organ index, serum levels of SOD, CAT, GSH-PX, ALT, AST and MDA, IL-2, IL-4, IL10 and IFN-γ in aging mice. The results showed that the body weight of model group was significantly different from that of CK (0) mice (P<0.01), and the body weight of high, middle and low dose mice were significantly different (P<0.05), After oral administration, the hypoxia tolerance time and swimming time of OL group mice were the shortest, while the high dose OZT group mice had the longest time, compared with VE group, there was no significant difference (P<0.05); OZT could also decrease the activities of ALT, AST, SOD, CAT and GSH-Px in serum of senescent mice,and enhanced the production of IL-2, IL-4 and IFN-γ, the effects of high-dose OZT was significantly better than that of OL and similar to that of VE. In conclusion, OZT has a good intervention effect on the subacute aging model induced by D-galactose, which can effectively improve the anti-oxidation ability of mice, prolong the anti-hypoxia time and improve the anti-fatigue effect, and delay the aging effect.

甘肃省科技重大专项（21ZD4NK045）；甘肃省重点研发计划项目（22YF7FK220）；甘肃省高校教师创新基金项目（2024B-335）