二十八烷醇生物活性及开发应用的研究进展

Reasearch progress on biological activity and application development of octacosanol

摘要:

二十八烷醇作为国家严格认证的食品添加剂,在中草药资源中蕴藏丰富,还具有降血脂、抗疲劳、防治心血管疾病等多种药理活性。目前,利用纳米、微囊、环糊精包合等高新技术,有效提高了二十八烷醇的生物利用度,推进了其在医疗、保健、食品以及饲料领域的广泛应用。然而,由于我国对二十八烷醇的研究起步较晚,再加上技术限制,其提取工艺、资源开发及规模化生产有待深入研究。本文对二十八烷醇的天然植物资源进行归纳整理,对其制备合成、体内吸收代谢及药理作用进行综述；同时,应用文献计量学的方法,分析了二十八烷醇在国内外的研究趋势和前沿热点,以期为二十八烷醇资源的开发利用及产品的研发提供理论基础。

Abstract:

As a food additive strictly certified by the state, octacosanol is rich in herbal resources, in addition to a variety of pharmacological activities such as lowering blood lipids, anti-fatigue, and prevention of cardiovascular diseases. At present, the use of nanometer, microencapsulation, cyclodextrin encapsulation and other high-tech has effectively improved the bioavailability of octacosanol, and promoted its wide application in the fields of medicine, health care, food and feed. However, due to the late start of the research on octacosanol in China, coupled with the technical limitations, its related extraction process, resource development and large-scale production are yet to be studied in depth. In this paper, the natural plant resources of octacosanol are summarized, and their preparation, synthesis, in vivo absorption and metabolism, and pharmacological effects are reviewed; at the same time, the bibliometric method is applied to analyze the research trends and hotspots of octacosanol at home and abroad, to provide theoretical bases for the exploitation and utilization of octacosanol resources and the research and development of octacosanol products.